COMPREHENSIVE CHARACTERIZATION OF TOXOPLASMA ACYL COENZYME A-BINDING PROTEIN TGACBP2 AND ITS CRITICAL ROLE IN PARASITE CARDIOLIPIN METABOLISM

Comprehensive Characterization of Toxoplasma Acyl Coenzyme A-Binding Protein TgACBP2 and Its Critical Role in Parasite Cardiolipin Metabolism

ABSTRACT Acyl coenzyme A (CoA)-binding protein (ACBP) can bind acyl-CoAs with high specificity and affinity, thus playing multiple roles in cellular functions.Mitochondria of the apicomplexan parasite Toxoplasma gondii have emerged as key organelles for lipid metabolism and signaling transduction.However, the rationale for how this parasite utilize

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Predicting effectiveness of countermeasures during the COVID-19 outbreak in South Africa using agent-based simulation

Abstract COVID-19 has spread rapidly around the globe.While there has been a slow down of the spread in some countries, e.g., in China, the African continent is still at the beginning of a potentially wide spread of the virus.Owing to its economic strength and imbalances, South Africa is of particular relevance with regard to the drastic measures t

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Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice

Abstract Background Debate exists as to whether welding fume is carcinogenic, but epidemiological evidence suggests that welders are an at risk population for the development of lung cancer.Recently, we found that exposure to welding fume caused an acutely greater and prolonged lung inflammatory response in lung tumor susceptible A/J versus resista

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